Feng Yongheng. review, the role of the lncRNA HOTAIR in HCC is examined. As an oncogenic lncRNA, HOTAIR promotes the development of most, if not all, ... III, and IV, respectively. Z.-J. Discovery of the HOTAIR gene HOTAIR was discovered by Howard Chang’s group as a lncRNA that recruits Polycomb Repressive Complex 2 (PRC2), a transcriptional co-repressor, to repress the expression of the homeobox gene D cluster (HOXD) [ 39 ]. CONCLUSIONS: LncRNA HOTAIR activates the expression of NF-κB in myeloma cells and promotes the proliferation of myeloma cells. To investigate the expression of HOX transcript antisense RNA (HOTAIR) in cardiac tissues and plasma of patients with congenital heart diseases (CHDs). The upregulation of HOTAIR has also been induced upon FFA-treated HepG2 cells via NF-κB signaling. Department of General Surgery, Nanjing First Hospital, Nanjing Medical University, Nanjing, China . Ultimately, the relationship of this lncRNA with different therapeutic approaches is discussed. Clinical values of HOTAIR in HCC 6. HOTAIR … The HOTAIR lncRNA: A remarkable oncogenic promoter in human cancer metastasis (Review) LILI CHEN*, XINLE QIAN*, ZHONGQI WANG and XIQIU ZHOU Department of Medical Oncology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, P.R. In this review, we briefly discuss the structure of HOTAIR in the context of genome and impact of this lncRNA on normal human development. LncRNA HOTAIR is deregulated in hepatocellular and colorectal carcinomas, pancreatic tumors, ovarian cancer, and sarcomas [23,24,25,26,27]. HOTAIR/miRNAs complexes interfere with different cellular processes during carcinogenesis, mainly deregulating a series of oncogenic signaling pathways. D.-D. Ma, L.-L. uan, L.-. In this review, we describe the experimental evidences on the potential role as circulating marker of lncRNA HOTAIR. In this review, we summarized the latest advances regarding the role of HOTAIR in cervical cancer with an emphasis on its diagnostic and prognostic values. ChIRP-seq is generally applicable to illuminate the intersection of RNA and chromatin with newfound precision genome wide. Fan, .-L. Sun, . In particular, aberrant expression of HOX transcript antisense intergenic RNA (HOTAIR) lncRNA plays an important role in BC contributing to its progression and represents a predictor of BC metastasis. Contents 1. Be-sides, its … Osteopontin plays critical roles in osteoarthritis (OA) by regulating the functions of osteoclasts. The standard working solution was diluted to be prepared into the standard working solution at a concentration of 2000, 1000, 500, 250, 125, 62.5, 31.25 and 0 pg/mL. Lin 5144 of gene transcription, post-transcriptional regu-lation, and epigenetic regulation. The HOTAIR lncRNA is transcribed from the HOXC locus and functions in the binding, and the recruitment and binding of the LSD1 and PRC2 complex to the HOXD locus. To cite this article. We also present the molecular function and regulation of this lncRNA in different types of cancer. In 2007, Rinn et al. Contribution: Conceptualization (equal), Data curation (equal), Software (equal) Search for more papers by this author. Long non-coding RNAs (lincRNAs), a relatively recently recognized class of widely transcribed genes, are thought to affect chromatin state and epigenetic regulation, but their mechanisms of … The potential use of HOTAIR as a biomarker to achieve more accurate prognostic predictions and as an effective therapeutic target for HCC is then discussed. Eur Rev Med Pharmacol Sci Year: 2019 Vol. Various studies have revealed that lncRNA HO-TAIR is highly expressed in many tumors, which is involved in tumor invasion and metastasis. To obtain comprehensive insight of HOTAIR in lung cancer, we integrate mechanistic studies of HOTAIR in other types of cancer in our review. Objective . Jiang, M.-Y. Free PDF Download. In this review, we discuss the studies from the past 6 years on the HOTAIR lncRNA, with a focus on HOTAIR's identification, functional characterization, clinical implications, and regulation of gene expression in carcinogenesis and cancer metastasis. This study was carried out to investigate the role of HOTAIR in OA. In this review, we summarize recent research on HOTAIR lncRNA, with a focus on its identification, characterization, mechanism of action, and association with related human cancers. HOTAIR is 2148 nucleotides long lncRNA associated with Sporadic Thoracic Aortic Aneurysm through regulation of extracellular matrix deposition and apoptosis of human aortic smooth muscle cells. Chromatin. In the lncRNA H19, the rs2735971 A/G, rs2839698C/T, and rs3024270 G/C polymorphisms, but not rs217727C/T, were correlated with overall cancer risk. PRC2, which includes EZH2 and SUZ12, trimethylates H3 lysine K27 (H3K27me3) resulting in epigenetic silencing. lncRNA. Keywords Related articles: MiR-203 is involved in osteoporosis by regulating DKK1 and inhibiting osteogenic differentiation of MSCs ; MiR-203 is essential for the shift … Moreover, HOTAIR is pervasively overexpressed in most human cancers compared with noncancerous adjacent tissues. Despite considering vast majority … Functions of HOTAIR in HCC 5. The 5´end of HOTAIR interacts with chromatin remodeling complexes such as polycomb repressive complex 2 (PRC2) or the LSD1/ REST/CoREST complex [ 78 ] and leads to silencing of genes on the HoxD cluster. HOTAIR is a 2.2 kb long lncRNA that is transcribed from antisense strand of HOXC gene cluster present in chromosome 12 .Like protein coding genes, HOTAIR is transcribed by RNA polymerase II, spliced, polyadenylated and 5′-capped , , .HOTAIR was originally discovered based on tiling microarray analysis by Rinn et al. lncRNA HOTAIR knockdown suppresses gastric cancer cell biological activities. B.-Z. Cancer. Here we review recent data on the critical role of HOTAIR in human malignancy and its potential mechanism of action. The potential use of HOTAIR as a biomarker to achieve more accurate prognostic predictions and as an effective therapeutic target for HCC is then discussed. HOTAIR gene is located on chromosome 12 inside the HoxC locus, specifically between HoxC11 and HoxC12. All patients signed informed consent and this study passed the review of Ethic Committee of Integrated Hospital of Traditional Chinese Medicine, Southern Medicine University. LncRNA HOTAIR promotes colon cancer 5753 molecular mechanism of colon cancer carcino-genesis and metastasis can help to establish rea-sonable prevention and treatment programs and to improve long-term survival and quality of life15. HOTAIR lncRNA preferentially occupies a GA-rich DNA motif to nucleate broad domains of Polycomb occupancy and histone H3 lysine 27 trimethylation. hang, .-W. HOTAIR has been Kromrey Middle School A B Day Schedule,
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